Abrogation of Notch Signaling in Embryonic TECs Impacts Postnatal mTEC Homeostasis and Thymic Involution

Abrogation of Notch Signaling in Embryonic TECs Impacts Postnatal mTEC Homeostasis and Thymic Involution

Notch signaling is crucial for fate specification and maturation of thymus-seeding progenitors along the T-cell lineage. Recent studies have extended the role of Notch signaling to thymic epithelial cells (TECs), showing that Notch regulates TEC progenitor maintenance and emergence of medullary TECs...

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Bibliographic Details
Main Authors: María Jesús García-León, Marta Mosquera, Carmela Cela, Juan Alcain, Saulius Zuklys, Georg Holländer, María L. Toribio
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-05-01
Series:Frontiers in Immunology
Subjects:
thymus
notch
thymic epithelial cells
premature degeneration
thymic involution
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.867302/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2022.867302/full

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