Penetration Efficiency of Antitumor Agents in Ovarian Cancer Spheroids: The Case of Recombinant Targeted Toxin DARPin-LoPE and the Chemotherapy Drug, Doxorubicin

Penetration Efficiency of Antitumor Agents in Ovarian Cancer Spheroids: The Case of Recombinant Targeted Toxin DARPin-LoPE and the Chemotherapy Drug, Doxorubicin

The efficiency of delivering a therapeutic agent into a tumor is among the crucial factors determining the prospects for its clinical use. This problem is particularly acute in the case of targeted antitumor agents since many of them are high-molecular-weight compounds. In this work, the penetration...

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Bibliographic Details
Main Authors: Evgeniya Sokolova, Olga Kutova, Alena Grishina, Anton Pospelov, Evgeniy Guryev, Alexey Schulga, Sergey Deyev, Irina Balalaeva
Format: Article
Language:English
Published: MDPI AG 2019-05-01
Series:Pharmaceutics
Subjects:
drug penetration into tumor
HER2
spheroid
targeted therapy
targeted toxin
DARPin
<i>Pseudomonas</i> exotoxin A
Online Access:https://www.mdpi.com/1999-4923/11/5/219

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https://www.mdpi.com/1999-4923/11/5/219

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