Lico A Causes ER Stress and Apoptosis via Up-Regulating miR-144-3p in Human Lung Cancer Cell Line H292

Lico A Causes ER Stress and Apoptosis via Up-Regulating miR-144-3p in Human Lung Cancer Cell Line H292

During our study on the bioactivities of natural flavonoids, we found that the total flavonoids (TFs) and the main constituent of it, licochalcone A (lico A), activated unfolded protein response (UPR) and induced autophagy and thereby apoptosis in H292 cells. MicroRNAs, such as the tumor repressor m...

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Bibliographic Details
Main Authors: Gang Chen, Yueping Ma, Zhe Jiang, Yuan Feng, Yueqing Han, Yetian Tang, Juan Zhang, Hui Ni, Xuezheng Li, Ning Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-07-01
Series:Frontiers in Pharmacology
Subjects:
autophagy
apoptosis
CHOP
miR-144-3p
homology modeling
docking
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2018.00837/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2018.00837/full

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