Low CDK Activity and Enhanced Degradation by APC/C<sup>CDH1</sup> Abolishes CtIP Activity and Alt-EJ in Quiescent Cells

Low CDK Activity and Enhanced Degradation by APC/C<sup>CDH1</sup> Abolishes CtIP Activity and Alt-EJ in Quiescent Cells

Alt-EJ is an error-prone DNA double-strand break (DSBs) repair pathway coming to the fore when first-line repair pathways, c-NHEJ and HR, are defective or fail. It is thought to benefit from DNA end-resection—a process whereby 3′ single-stranded DNA-tails are generated—initiated by the CtIP/MRE11-RA...

Full description

Bibliographic Details
Main Authors: Fanghua Li, Emil Mladenov, Yanjie Sun, Aashish Soni, Martin Stuschke, Beate Timmermann, George Iliakis
Format: Article
Language:English
Published: MDPI AG 2023-06-01
Series:Cells
Subjects:
ionizing radiation
DNA repair
repair of DNA double-strand breaks
alt-EJ
DNA end-resection
CtIP
Online Access:https://www.mdpi.com/2073-4409/12/11/1530

Internet

https://www.mdpi.com/2073-4409/12/11/1530

Similar Items