Detection of transient abnormal myelopoiesis blasts in a liver biopsy specimen by double-immunostaining for full-length GATA1 and CD42b

Detection of transient abnormal myelopoiesis blasts in a liver biopsy specimen by double-immunostaining for full-length GATA1 and CD42b

ABSTRACTBackground Transient abnormal myelopoiesis (TAM) is characterized by leukocytosis with increased circulating megakaryoblasts that harbor N-terminal truncating mutations in the GATA1 gene. Approximately 10% of affected patients experience early death.Observations A 2-month-old boy with Down s...

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Bibliographic Details
Main Authors: Azusa Haba, Yuko Imaizumi, Daichi Hayashi, Shiho Yasue, Hiroki Otsuka, Saori Endo, Michio Ozeki, Kazuhiro Kobayashi, Tatsuhiko Miyazaki, Akira Hara, Hidenori Ohnishi
Format: Article
Language:English
Published: Taylor & Francis Group 2023-12-01
Series:Hematology
Subjects:
Down syndrome
GATA-binding factor 1
Liver fibrosis
Transient leukemia of Down syndrome
Transient myeloproliferative disorder
Online Access:https://www.tandfonline.com/doi/10.1080/16078454.2023.2240135

Internet

https://www.tandfonline.com/doi/10.1080/16078454.2023.2240135

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