Modulation of P2X7 Receptor during Inflammation in Multiple Sclerosis

Modulation of P2X7 Receptor during Inflammation in Multiple Sclerosis

Multiple sclerosis (MS) is characterized by macrophage accumulation and inflammatory infiltrates into the CNS contributing to demyelination. Because purinergic P2X7 receptor (P2X7R) is known to be abundantly expressed on cells of the hematopoietic lineage and of the nervous system, we further invest...

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Bibliographic Details
Main Authors: Susanna Amadio, Chiara Parisi, Eleonora Piras, Paola Fabbrizio, Savina Apolloni, Cinzia Montilli, Sabina Luchetti, Serena Ruggieri, Claudio Gasperini, Franco Laghi-Pasini, Luca Battistini, Cinzia Volonté
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-11-01
Series:Frontiers in Immunology
Subjects:
astrocytes
monocyte chemoattractant protein-1
monocytes
multiple sclerosis
neuroinflammation
P2X7 receptor
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2017.01529/full

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http://journal.frontiersin.org/article/10.3389/fimmu.2017.01529/full

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