Molecular Basis of the Ternary Interaction between NS1 of the 1918 Influenza A Virus, PI3K, and CRK

Molecular Basis of the Ternary Interaction between NS1 of the 1918 Influenza A Virus, PI3K, and CRK

The 1918 influenza A virus (IAV) caused the worst flu pandemic in human history. Non-structural protein 1 (NS1) is an important virulence factor of the 1918 IAV and antagonizes host antiviral immune responses. NS1 increases virulence by activating phosphoinositide 3-kinase (PI3K) via binding to the...

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Bibliographic Details
Main Authors: Alyssa Dubrow, Sirong Lin, Nowlan Savage, Qingliang Shen, Jae-Hyun Cho
Format: Article
Language:English
Published: MDPI AG 2020-03-01
Series:Viruses
Subjects:
1918 influenza a virus
nonstructural protein 1
crk
pi3k
ternary interaction
Online Access:https://www.mdpi.com/1999-4915/12/3/338

Internet

https://www.mdpi.com/1999-4915/12/3/338

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