Modelling altered signalling of G-protein coupled receptors in inflamed environment to advance drug design

Modelling altered signalling of G-protein coupled receptors in inflamed environment to advance drug design

Abstract We previously reported the successful design, synthesis and testing of the prototype opioid painkiller NFEPP that does not elicit adverse side effects. The design process of NFEPP was based on mathematical modelling of extracellular interactions between G-protein coupled receptors (GPCRs) a...

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Bibliographic Details
Main Authors: Arne Thies, Vikram Sunkara, Sourav Ray, Hanna Wulkow, M. Özgür Celik, Fatih Yergöz, Christof Schütte, Christoph Stein, Marcus Weber, Stefanie Winkelmann
Format: Article
Language:English
Published: Nature Portfolio 2023-01-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-023-27699-w

Internet

https://doi.org/10.1038/s41598-023-27699-w

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