Pharmacokinetic–pharmacodynamic analysis of cefmetazole against extended-spectrum β-lactamase-producing Enterobacteriaceae in dogs using Monte Carlo Simulation

Pharmacokinetic–pharmacodynamic analysis of cefmetazole against extended-spectrum β-lactamase-producing Enterobacteriaceae in dogs using Monte Carlo Simulation

IntroductionThe spread of extended-spectrum β-lactamase-producing Enterobacteriaceae (ESBL-E) is a serious concern in companion animal medicine owing to their ability to develop multidrug resistance. Cefmetazole (CMZ) is a candidate drug for treating ESBL-E infections; however, its regimen in dogs h...

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Bibliographic Details
Main Authors: Mizuki Kusumoto, Tomoki Motegi, Haruna Uno, Mizuki Yokono, Kazuki Harada
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-09-01
Series:Frontiers in Veterinary Science
Subjects:
cefmetazole
extended-spectrum β-lactamase
Enterobacteriaceae
Monte Carlo Simulation
dog
pharmacokinetics
Online Access:https://www.frontiersin.org/articles/10.3389/fvets.2023.1270137/full

Internet

https://www.frontiersin.org/articles/10.3389/fvets.2023.1270137/full

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