Rechallenge of denosumab in advanced giant cell tumor of the bone after atypical femur fracture: A case report and review of literature

Rechallenge of denosumab in advanced giant cell tumor of the bone after atypical femur fracture: A case report and review of literature

Giant cell tumor of the bone (GCTB) is a locally aggressive neoplasm where surgery is often curative. However, it can rarely give rise to distant metastases. Currently, the only available active therapeutic option for unresectable GCTB is denosumab, an anti-RANKL monoclonal antibody that dampens the...

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Bibliographic Details
Main Authors: Vincenzo Nasca, Anna Maria Frezza, Carlo Morosi, Ciriaco Buonomenna, Antonina Parafioriti, Giorgio Zappalà, Federica Bini, Paolo Giovanni Casali, Mattia Loppini, Silvia Stacchiotti
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-07-01
Series:Frontiers in Oncology
Subjects:
denosumab
giant cell tumor of bone
sarcoma
atypical femur fracture
bone tumor
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2022.953149/full

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https://www.frontiersin.org/articles/10.3389/fonc.2022.953149/full

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