Dynamic regulation of mitochondrial pyruvate metabolism is necessary for orthotopic pancreatic tumor growth

Dynamic regulation of mitochondrial pyruvate metabolism is necessary for orthotopic pancreatic tumor growth

Abstract Background Pyruvate dehydrogenase complex (PDC) plays a central role in carbohydrate metabolism, linking cytoplasmic glycolysis to the mitochondrial tricarboxylic acid (TCA) cycle. PDC is a conserved E1-E2-E3 dehydrogenase with a PDHA1 and PDHB heterotetramer functioning as the E1 subunit....

Full description

Bibliographic Details
Main Authors: Nancy P. Echeverri Ruiz, Vijay Mohan, Jinghai Wu, Sabina Scott, McKenzie Kreamer, Martin Benej, Tereza Golias, Ioanna Papandreou, Nicholas C. Denko
Format: Article
Language:English
Published: BMC 2021-11-01
Series:Cancer & Metabolism
Subjects:
Hypoxia
Glucose metabolism
Orthotopic pancreatic tumors
Pyruvate dehydrogenase
Mitochondria
Online Access:https://doi.org/10.1186/s40170-021-00275-4

Internet

https://doi.org/10.1186/s40170-021-00275-4

Similar Items