Adamantaniline Derivatives Target ATP5B to Inhibit Translation of Hypoxia Inducible Factor‐1α

Adamantaniline Derivatives Target ATP5B to Inhibit Translation of Hypoxia Inducible Factor‐1α

Abstract Hypoxia inducible factor‐1α (HIF‐1α) plays a critical role in cellular adaptation to hypoxia and it is a potential therapeutic target for anti‐cancer drugs. Applying high‐throughput screening, here it is found that HI‐101, a small molecule containing an adamantaniline moiety, effectively re...

Full description

Bibliographic Details
Main Authors: Huiti Li, Yali Liu, Zian Xue, Li Zhang, Xiaoxue Ruan, Jintong Yang, Zhongjiao Fan, Hongfang Zhao, Yu Cao, Guoqiang Chen, Ying Xu, Lu Zhou
Format: Article
Language:English
Published: Wiley 2023-09-01
Series:Advanced Science
Subjects:
adamantaniline derivatives
ATP5B
HIF‐1α
target identification
Online Access:https://doi.org/10.1002/advs.202301071

Internet

https://doi.org/10.1002/advs.202301071

Similar Items