Label-Free Potentiometry for Detecting DNA Hybridization Using Peptide Nucleic Acid and DNA Probes

Label-Free Potentiometry for Detecting DNA Hybridization Using Peptide Nucleic Acid and DNA Probes

Peptide nucleic acid (PNA) has outstanding affinity over DNA for complementary nucleic acid sequences by forming a PNA-DNA heterodimer upon hybridization via Watson-Crick base-pairing. To verify whether PNA probes on an electrode surface enhance sensitivity for potentiometric DNA detection or not, w...

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Bibliographic Details
Main Authors: Yuji Miyahara, Hiroshi Aoki, Masaki Torimura, Ankit Balram Singi, Akira Matsumoto, Yasuhiro Maeda, Tatsuro Goda
Format: Article
Language:English
Published: MDPI AG 2013-02-01
Series:Sensors
Subjects:
PNA
DNA
hybridization
electrostatic energy
label-free biosensor
potentiometry
Online Access:http://www.mdpi.com/1424-8220/13/2/2267

Internet

http://www.mdpi.com/1424-8220/13/2/2267

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