Raddeanin A Enhances Mitochondrial DNA‐cGAS/STING Axis‐Mediated Antitumor Immunity by Targeting Transactive Responsive DNA‐Binding Protein 43

Raddeanin A Enhances Mitochondrial DNA‐cGAS/STING Axis‐Mediated Antitumor Immunity by Targeting Transactive Responsive DNA‐Binding Protein 43

Abstract Immune checkpoint therapies (ICT) have achieved unprecedented efficacy in multiple cancer treatments, but are still limited by low clinical response rates. Identification of immunogenic cell death (ICD)‐inducing drugs that can induce tumor cell immunogenicity and reprogram the tumor microen...

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Bibliographic Details
Main Authors: Mingxiao Yin, Jingwen Dong, Cuicui Sun, Xiaojia Liu, Zhirui Liu, Lu Liu, Zean Kuang, Na Zhang, Dian Xiao, Xinbo Zhou, Hongbin Deng
Format: Article
Language:English
Published: Wiley 2023-05-01
Series:Advanced Science
Subjects:
dendritic cells
immune checkpoint therapies
immunogenic cell death
STING
transactive responsive DNA‐binding protein 43
Online Access:https://doi.org/10.1002/advs.202206737

Internet

https://doi.org/10.1002/advs.202206737

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