Pyrrolizine/indolizine-cinnamaldehyde Schiff bases: Design, synthesis, biological evaluation, ADME, and molecular docking study

In the present study, two new Schiff bases 10a,b were synthesized by the condensation of 9a,b with cinnamaldehyde. The chemical structures of 10a,b were confirmed using spectral (IR, mass, 1H NMR, 13C NMR, and DEPT C135) and elemental analysis. The effect of 10a,b on the viability of five (SKOV-3, H...

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Bibliographic Details
Main Authors: Mohammed A.S. Abourehab, Alaa M. Alqahtani, Faisal A. Almalki, Ashraf N. Abdalla, Ahmed M. Gouda
Format: Article
Language:English
Published: Elsevier 2022-04-01
Series:European Journal of Medicinal Chemistry Reports
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S2772417422000085