Dendritic peptide-conjugated polymeric nanovectors for non-toxic delivery of plasmid DNA and enhanced non-viral transfection of immune cells

Dendritic peptide-conjugated polymeric nanovectors for non-toxic delivery of plasmid DNA and enhanced non-viral transfection of immune cells

Summary: Plasmid DNA (pDNA) transfection is advantageous for gene therapies requiring larger genetic elements, including “all-in-one” CRISPR/Cas9 plasmids, but is limited by toxicity as well as poor intracellular release and transfection efficiency in immune cell populations. Here, we developed a sy...

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Bibliographic Details
Main Authors: Sijia Yi, Sun-Young Kim, Michael P. Vincent, Simseok A. Yuk, Sharan Bobbala, Fanfan Du, Evan Alexander Scott
Format: Article
Language:English
Published: Elsevier 2022-07-01
Series:iScience
Subjects:
Health sciences
Drug delivery system
Biological sciences
Immunology
Biotechnology
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004222008276

Internet

http://www.sciencedirect.com/science/article/pii/S2589004222008276

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