Homeodomain proteins hierarchically specify neuronal diversity and synaptic connectivity

Homeodomain proteins hierarchically specify neuronal diversity and synaptic connectivity

How our brain generates diverse neuron types that assemble into precise neural circuits remains unclear. Using Drosophila lamina neuron types (L1-L5), we show that the primary homeodomain transcription factor (HDTF) brain-specific homeobox (Bsh) is initiated in progenitors and maintained in L4/L5 ne...

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Bibliographic Details
Main Authors: Chundi Xu, Tyler B Ramos, Edward M Rogers, Michael B Reiser, Chris Q Doe
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2024-01-01
Series:eLife
Subjects:
homeodomain
lamina
neuronal diversity
synaptic connectivity
feed-forward loop
DIP-β
Online Access:https://elifesciences.org/articles/90133

Internet

https://elifesciences.org/articles/90133

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