Defining the structural basis for human alloantibody binding to human leukocyte antigen allele HLA-A*11:01

Defining the structural basis for human alloantibody binding to human leukocyte antigen allele HLA-A*11:01

Anti-human leukocyte antigen (HLA) antibodies are important mediators of alloresponses, but structural insights on antibody:HLA interaction are still lacking. Here the authors provide a 2.4 Å structure of antibody:HLA complex, and also analyse HLA features important for other HLA-interacting molecul...

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Bibliographic Details
Main Authors: Yue Gu, Yee Hwa Wong, Chong Wai Liew, Conrad E. Z. Chan, Tanusya M. Murali, Jiawei Yap, Chien Tei Too, Kiren Purushotorman, Maryam Hamidinia, Abbas El Sahili, Angeline T. H. Goh, Rachel Z. C. Teo, Kathryn J. Wood, Brendon J. Hanson, Nicholas R. J. Gascoigne, Julien Lescar, Anantharaman Vathsala, Paul A. MacAry
Format: Article
Language:English
Published: Nature Portfolio 2019-02-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-019-08790-1
Description
Summary:Anti-human leukocyte antigen (HLA) antibodies are important mediators of alloresponses, but structural insights on antibody:HLA interaction are still lacking. Here the authors provide a 2.4 Å structure of antibody:HLA complex, and also analyse HLA features important for other HLA-interacting molecules, to enhance our understanding of alloimmunity.
ISSN:2041-1723

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