Preclinical Pharmacokinetics and Biodistribution of LR004, a Novel Antiepidermal Growth Factor Receptor Monoclonal Antibody

Preclinical Pharmacokinetics and Biodistribution of LR004, a Novel Antiepidermal Growth Factor Receptor Monoclonal Antibody

LR004 is a novel chimeric (human/mouse) monoclonal antibody developed for the treatment of advanced colorectal carcinoma with detectable epidermal growth factor receptor (EGFR) expression. We aimed to investigate the preclinical pharmacokinetics (PK) and in vivo biodistribution of LR004. The PK prof...

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Bibliographic Details
Main Authors: Ying Zheng, Guifang Dou, Shuchen Liu, Zhiyun Meng, Eric I. Tsao, Gang Yu, Xiaoxia Zhu, Ruolan Gu, Zhuona Wu, Yunbo Sun, Peng Han, Hui Gan
Format: Article
Language:English
Published: MDPI AG 2024-01-01
Series:Molecules
Subjects:
monoclonal antibody
EGFR
tumor-targeting
pharmacokinetics
radionuclide-based biodistribution
nanoSPECT/CT
Online Access:https://www.mdpi.com/1420-3049/29/2/545

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https://www.mdpi.com/1420-3049/29/2/545

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