Long-term adaptation following influenza A virus host shifts results in increased within-host viral fitness due to higher replication rates, broader dissemination within the respiratory epithelium and reduced tissue damage.

Long-term adaptation following influenza A virus host shifts results in increased within-host viral fitness due to higher replication rates, broader dissemination within the respiratory epithelium and reduced tissue damage.

The mechanisms and consequences of genome evolution on viral fitness following host shifts are poorly understood. In addition, viral fitness -the ability of an organism to reproduce and survive- is multifactorial and thus difficult to quantify. Influenza A viruses (IAVs) circulate broadly among wild...

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Bibliographic Details
Main Authors: Julien A R Amat, Veronica Patton, Caroline Chauché, Daniel Goldfarb, Joanna Crispell, Quan Gu, Alice M Coburn, Gaelle Gonzalez, Daniel Mair, Lily Tong, Luis Martinez-Sobrido, John F Marshall, Francesco Marchesi, Pablo R Murcia
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2021-12-01
Series:PLoS Pathogens
Online Access:https://doi.org/10.1371/journal.ppat.1010174

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https://doi.org/10.1371/journal.ppat.1010174

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