Lacking P2X7-receptors protects substantia nigra dopaminergic neurons and hippocampal-related cognitive performance from the deleterious effects of high-fat diet exposure in adult male mice

Lacking P2X7-receptors protects substantia nigra dopaminergic neurons and hippocampal-related cognitive performance from the deleterious effects of high-fat diet exposure in adult male mice

BackgroundDietary fat consumption, involved in the pathogenesis of insulin resistance and impaired glucose metabolism, is linked with decline in cognitive functions, dementia, and development of Parkinson’s disease and Alzheimer’s disease. Mature IL-1β, requiring the activation of the P2X7 receptor...

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Bibliographic Details
Main Authors: Chiara Rossi, Mariarosaria Distaso, Francesco Raggi, Claudia Kusmic, Francesco Faita, Anna Solini
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-01-01
Series:Frontiers in Nutrition
Subjects:
brain
high fat diet
insulin
parkin
P2X7 receptor
Online Access:https://www.frontiersin.org/articles/10.3389/fnut.2024.1289750/full

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https://www.frontiersin.org/articles/10.3389/fnut.2024.1289750/full

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