In vitro evaluation of dihydropyridine-3-carbonitriles as potential cytotoxic agents through PIM-1 protein kinase inhibition

In vitro evaluation of dihydropyridine-3-carbonitriles as potential cytotoxic agents through PIM-1 protein kinase inhibition

PIM-1 protein kinase inhibitor belongs to a novel class of serine/threonine kinases. As PIM-1 is overexpressed in cancer cells and possesses oncogenic functions, its inhibition provides a new option in cancer therapy. In this study, in vitro inhibitory effects of seven analogues of 1, 2-dihydropyrid...

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Bibliographic Details
Main Authors: Khalil Abnous, Hesam Manavi, Soghra Mehri, Mona Alibolandi, Hossein Kamali, Morteza Ghandadi, Farzin Hadizadeh
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2017-01-01
Series:Research in Pharmaceutical Sciences
Subjects:
pim-1; protein kinase inhibition; dihydropyridine-3- carbonitrile; anticancer; cytotoxicity
Online Access:http://www.rpsjournal.net/article.asp?issn=1735-5362;year=2017;volume=12;issue=3;spage=196;epage=203;aulast=Abnous

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http://www.rpsjournal.net/article.asp?issn=1735-5362;year=2017;volume=12;issue=3;spage=196;epage=203;aulast=Abnous

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