Temporal phosphoproteomics reveals circuitry of phased propagation in insulin signaling

Temporal phosphoproteomics reveals circuitry of phased propagation in insulin signaling

Abstract Insulin is a pleiotropic hormone that elicits its metabolic and mitogenic actions through numerous rapid and reversible protein phosphorylations. The temporal regulation of insulin’s intracellular signaling cascade is highly complex and insufficiently understood. We conduct a time-resolved...

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Bibliographic Details
Main Authors: Michael Turewicz, Christine Skagen, Sonja Hartwig, Stephan Majda, Kristina Thedinga, Ralf Herwig, Christian Binsch, Delsi Altenhofen, D. Margriet Ouwens, Pia Marlene Förster, Thorsten Wachtmeister, Karl Köhrer, Torben Stermann, Alexandra Chadt, Stefan Lehr, Tobias Marschall, G. Hege Thoresen, Hadi Al-Hasani
Format: Article
Language:English
Published: Nature Portfolio 2025-02-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-56335-6

Internet

https://doi.org/10.1038/s41467-025-56335-6

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