Fragment-Based Discovery of AF9 YEATS Domain Inhibitors

Fragment-Based Discovery of AF9 YEATS Domain Inhibitors

YEATS (YAF9, ENL, AF9, TAF14, SAS5) family proteins recognize acylated histones and in turn regulate chromatin structure, gene transcription, and stress signaling. The chromosomal translocations of ENL and mixed lineage leukemia are considered oncogenic drivers in acute myeloid leukemia and acute ly...

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Bibliographic Details
Main Authors: Yaqian Liu, Ruoxing Jin, Hui Lu, Kangjie Bian, Rui Wang, Lei Wang, Rui Gao, Jiahai Zhang, Jihui Wu, Xuebiao Yao, Xing Liu, Dan Liu, Xisheng Wang, Zhiyong Zhang, Ke Ruan
Format: Article
Language:English
Published: MDPI AG 2022-03-01
Series:International Journal of Molecular Sciences
Subjects:
fragment-based lead discovery
post-translational modification
histone acylation
YEATS domain
NMR fragment-based screening
Online Access:https://www.mdpi.com/1422-0067/23/7/3893

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https://www.mdpi.com/1422-0067/23/7/3893

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