The Novel Aminomethylcycline Omadacycline Has High Specificity for the Primary Tetracycline-Binding Site on the Bacterial Ribosome

The Novel Aminomethylcycline Omadacycline Has High Specificity for the Primary Tetracycline-Binding Site on the Bacterial Ribosome

Omadacycline is an aminomethylcycline antibiotic with potent activity against many Gram-positive and Gram-negative pathogens, including strains carrying the major efflux and ribosome protection resistance determinants. This makes it a promising candidate for therapy of severe infectious diseases. Om...

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Bibliographic Details
Main Authors: Corina G. Heidrich, Sanya Mitova, Andreas Schedlbauer, Sean R. Connell, Paola Fucini, Judith N. Steenbergen, Christian Berens
Format: Article
Language:English
Published: MDPI AG 2016-09-01
Series:Antibiotics
Subjects:
tetracycline
tigecycline
omadacycline
tetracycline resistance
antibiotics
antibiotic resistance
chemical probing
ribosome structure
Online Access:http://www.mdpi.com/2079-6382/5/4/32

Internet

http://www.mdpi.com/2079-6382/5/4/32

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