Quantifying the Cerebral Hemometabolic Response to Blood Transfusion in Pediatric Sickle Cell Disease With Diffuse Optical Spectroscopies

Quantifying the Cerebral Hemometabolic Response to Blood Transfusion in Pediatric Sickle Cell Disease With Diffuse Optical Spectroscopies

Red blood cell transfusions are common in patients with sickle cell disease who are at increased risk of stroke. Unfortunately, transfusion thresholds needed to sufficiently dilute sickle red blood cells and adequately restore oxygen delivery to the brain are not well defined. Previous work has show...

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Bibliographic Details
Main Authors: Seung Yup Lee, Rowan O. Brothers, Katherine B. Turrentine, Ayesha Quadri, Eashani Sathialingam, Kyle R. Cowdrick, Scott Gillespie, Shasha Bai, Adam E. Goldman-Yassen, Clinton H. Joiner, R. Clark Brown, Erin M. Buckley
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-07-01
Series:Frontiers in Neurology
Subjects:
diffuse correlation spectroscopy (DCS)
near-infrared spectroscopy
sickle cell disease (SCD)
blood transfusion
cerebral hemometabolics
cerebral oxygen extraction fraction
Online Access:https://www.frontiersin.org/articles/10.3389/fneur.2022.869117/full

Internet

https://www.frontiersin.org/articles/10.3389/fneur.2022.869117/full

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