Osteoporosis- and obesity-risk interrelationships: an epigenetic analysis of GWAS-derived SNPs at the developmental gene TBX15

Osteoporosis- and obesity-risk interrelationships: an epigenetic analysis of GWAS-derived SNPs at the developmental gene TBX15

A major challenge in translating findings from genome-wide association studies (GWAS) to biological mechanisms is pinpointing functional variants because only a very small percentage of variants associated with a given trait actually impact the trait. We used an extensive epigenetics, transcriptomic...

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Bibliographic Details
Main Authors: Xiao Zhang, Kenneth C. Ehrlich, Fangtang Yu, Xiaojun Hu, Xiang-He Meng, Hong-Wen Deng, Hui Shen, Melanie Ehrlich
Format: Article
Language:English
Published: Taylor & Francis Group 2020-07-01
Series:Epigenetics
Subjects:
gwas
osteoporosis
obesity
epigenetics
enhancers
promoters
transcription factor binding sites
dnasei hypersensitivity
osteoblasts
preadipocytes
Online Access:http://dx.doi.org/10.1080/15592294.2020.1716491

Internet

http://dx.doi.org/10.1080/15592294.2020.1716491

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