Poly (lactic-co-glycolic acid)-encapsulated iodine-131 nanoparticles fabricated with rhTSH induce apoptosis and immobilization of thyroid cancer cells

Poly (lactic-co-glycolic acid)-encapsulated iodine-131 nanoparticles fabricated with rhTSH induce apoptosis and immobilization of thyroid cancer cells

BackgroundAggressive thyroid carcinoma (ATC) usually loses radioiodine avidity to iodine-131 (131I) due to the downregulation of sodium/iodide symporter (NIS). The expression of thyroid stimulating hormone receptor (TSHR) is more persistent than NIS and the administration of recombinant human thyroi...

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Bibliographic Details
Main Authors: Yongzeng Fan, Yalan Xiong, Xinhong Wang, Jiahao Chen, Danzhou Fang, Jiahui Huang, Gengbiao Yuan
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-01-01
Series:Frontiers in Oncology
Subjects:
thyroid cancer
rhTSH
PLGA
iodine-131
apoptosis
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2023.1030105/full

Internet

https://www.frontiersin.org/articles/10.3389/fonc.2023.1030105/full

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