Unveiling the Multifaceted Roles of ISG15: From Immunomodulation to Therapeutic Frontiers

Unveiling the Multifaceted Roles of ISG15: From Immunomodulation to Therapeutic Frontiers

The Interferon Stimulated Gene 15 (ISG15), a unique Ubiquitin-like (Ubl) modifier exclusive to vertebrates, plays a crucial role in the immune system. Primarily induced by interferon (IFN) type I, ISG15 functions through diverse mechanisms: (i) covalent protein modification (ISGylation); (ii) non-co...

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Bibliographic Details
Main Authors: Enrique Álvarez, Michela Falqui, Laura Sin, Joseph Patrick McGrail, Beatriz Perdiguero, Rocío Coloma, Laura Marcos-Villar, Céline Tárrega, Mariano Esteban, Carmen Elena Gómez, Susana Guerra
Format: Article
Language:English
Published: MDPI AG 2024-02-01
Series:Vaccines
Subjects:
IFN
ISG15
ISGylation
vaccines
inflammation
immunity
Online Access:https://www.mdpi.com/2076-393X/12/2/153

Internet

https://www.mdpi.com/2076-393X/12/2/153

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