Graft-implanted, enzyme responsive, tacrolimus-eluting hydrogel enables long-term survival of orthotopic porcine limb vascularized composite allografts: A proof of concept study.

Graft-implanted, enzyme responsive, tacrolimus-eluting hydrogel enables long-term survival of orthotopic porcine limb vascularized composite allografts: A proof of concept study.

BACKGROUND:Currently, patients receiving vascularized composite allotransplantation (VCA) grafts must take long-term systemic immunosuppressive therapy to prevent immunologic rejection. The morbidity and mortality associated with these medications is the single greatest barrier to more patients bein...

Full description

Bibliographic Details
Main Authors: C Anton Fries, Shari D Lawson, Lin C Wang, Kai V Slaughter, Praveen K Vemula, Ashish Dhayani, Nitin Joshi, Jeffrey M Karp, Rory F Rickard, Vijay S Gorantla, Michael R Davis
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2019-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0210914

Internet

https://doi.org/10.1371/journal.pone.0210914

Similar Items