Novel Mutations in pncA Gene of Pyrazinamide Resistant Clinical Isolates of Mycobacterium tuberculosis

Novel Mutations in pncA Gene of Pyrazinamide Resistant Clinical Isolates of Mycobacterium tuberculosis

In clinical isolates of Mycobacterium tuberculosis (MTB), resistance to pyrazinamide occurs by mutations in any positions of the pncA gene (NC_000962.3) especially in nucleotides 359 and 374. In this study we examined the pncA gene sequence in clinical isolates of MTB. Genomic DNA of 33 clinical iso...

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Bibliographic Details
Main Authors: Manijeh Kahbazi, Hossein Sarmadian, Azam Ahmadi, Farshideh Didgar, Maryam Sadrnia, Toktam Poolad, Mohammad Arjomandzadegan
Format: Article
Language:English
Published: MDPI AG 2018-04-01
Series:Scientia Pharmaceutica
Subjects:
Mycobacterium tuberculosis
pyrazinamide
mutation
polymerase chain reaction
sequencing
Online Access:http://www.mdpi.com/2218-0532/86/2/15

Internet

http://www.mdpi.com/2218-0532/86/2/15

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