Molecular basis for substrate specificity of the Phactr1/PP1 phosphatase holoenzyme
PPP-family phosphatases such as PP1 have little intrinsic specificity. Cofactors can target PP1 to substrates or subcellular locations, but it remains unclear how they might confer sequence-specificity on PP1. The cytoskeletal regulator Phactr1 is a neuronally enriched PP1 cofactor that is controlle...
Main Authors: | , , , , , , , , , , |
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Format: | Article |
Language: | English |
Published: |
eLife Sciences Publications Ltd
2020-09-01
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Series: | eLife |
Subjects: | |
Online Access: | https://elifesciences.org/articles/61509 |