ERα-Targeting PROTAC as a Chemical Knockdown Tool to Investigate the Estrogen Receptor Function in Rat Menopausal Arthritis

ERα-Targeting PROTAC as a Chemical Knockdown Tool to Investigate the Estrogen Receptor Function in Rat Menopausal Arthritis

Proteolytic targeting chimeras (PROTACs) is a rapid and reversible chemical knockout method. Compared with traditional gene-editing tools, it can avoid potential genetic compensation, misunderstandings caused by spontaneous mutations, or gene knockouts that lead to embryonic death. To study the role...

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Bibliographic Details
Main Authors: Li Duan, Xiao Xu, Limei Xu, Caining Wen, Kan Ouyang, Zigang Li, Yujie Liang
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-11-01
Series:Frontiers in Pharmacology
Subjects:
PROTACs
estrogen receptor α
MMP-13
articular cartilage metabolism
menopausal arthritis
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2021.764154/full

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https://www.frontiersin.org/articles/10.3389/fphar.2021.764154/full

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