Cross-Reactivity to Mutated Viral Immune Targets Can Influence CD8+ T Cell Functionality: An Alternative Viral Adaptation Strategy

Cross-Reactivity to Mutated Viral Immune Targets Can Influence CD8+ T Cell Functionality: An Alternative Viral Adaptation Strategy

Loss of T cell immunogenicity due to mutations in virally encoded epitopes is a well-described adaptation strategy to limit host anti-viral immunity. Another described, but less understood, adaptation strategy involves the selection of mutations within epitopes that retain immune recognition, sugges...

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Bibliographic Details
Main Authors: Jennifer Currenti, Becker M.P. Law, Kai Qin, Mina John, Mark A. Pilkinton, Anju Bansal, Shay Leary, Ramesh Ram, Abha Chopra, Rama Gangula, Ling Yue, Christian Warren, Louise Barnett, Eric Alves, Wyatt J. McDonnell, Anuradha Sooda, Sonya L. Heath, Simon Mallal, Paul Goepfert, Spyros A. Kalams, Silvana Gaudieri
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-10-01
Series:Frontiers in Immunology
Subjects:
HIV
adaptation
host-viral interactions
T cell receptor
transcriptome
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.746986/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2021.746986/full

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