Novel therapeutic strategy for neurodegeneration by blocking Aβ seeding mediated aggregation in models of Alzheimer's disease

Novel therapeutic strategy for neurodegeneration by blocking Aβ seeding mediated aggregation in models of Alzheimer's disease

Aβ accumulation plays a central role in the pathogenesis of Alzheimer's disease (AD). Recent studies suggest that the process of Aβ nucleated polymerization is essential for Aβ fibril formation, pathology spreading and toxicity. Therefore, targeting this process represents an effective therapeu...

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Bibliographic Details
Main Authors: Simona Eleuteri, Saviana Di Giovanni, Edward Rockenstein, Mike Mante, Antony Adame, Margarita Trejo, Wolf Wrasidlo, Fang Wu, Patrick C. Fraering, Eliezer Masliah, Hilal A. Lashuel
Format: Article
Language:English
Published: Elsevier 2015-02-01
Series:Neurobiology of Disease
Subjects:
Alzheimer's disease
Aβ seeding-mediated aggregation
Aβ-propagation
Amyloid protein
Drug discovery
Inhibitors
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996114002484

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http://www.sciencedirect.com/science/article/pii/S0969996114002484

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