Development of Novel Faster-Dissolving Microneedle Patches for Transcutaneous Vaccine Delivery

Development of Novel Faster-Dissolving Microneedle Patches for Transcutaneous Vaccine Delivery

Microneedle (MN) patches are promising for transcutaneous vaccination because they enable vaccine antigens to physically penetrate the stratum corneum via low-invasive skin puncturing, and to be effectively delivered to antigen-presenting cells in the skin. In second-generation MN patches, the disso...

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Bibliographic Details
Main Authors: Akihiko Ono, Sayami Ito, Shun Sakagami, Hideo Asada, Mio Saito, Ying-Shu Quan, Fumio Kamiyama, Sachiko Hirobe, Naoki Okada
Format: Article
Language:English
Published: MDPI AG 2017-08-01
Series:Pharmaceutics
Subjects:
transcutaneous vaccine
faster-dissolving microneedle
carboxymethylcellulose
hyaluronan
clinical research
microneedle-dissolution kinetics in the skin
microneedle failure force
Online Access:https://www.mdpi.com/1999-4923/9/3/27

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https://www.mdpi.com/1999-4923/9/3/27

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