Genetic deletion of HVEM in a leukemia B cell line promotes a preferential increase of PD-1- stem cell-like T cells over PD-1+ T cells curbing tumor progression

Genetic deletion of HVEM in a leukemia B cell line promotes a preferential increase of PD-1- stem cell-like T cells over PD-1+ T cells curbing tumor progression

IntroductionA high frequency of mutations affecting the gene encoding Herpes Virus Entry Mediator (HVEM, TNFRSF14) is a common clinical finding in a wide variety of human tumors, including those of hematological origin.MethodsWe have addressed how HVEM expression on A20 leukemia cells influences tum...

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Bibliographic Details
Main Authors: Maria-Luisa del Rio, Carla Yago-Diez de Juan, Giovanna Roncador, Eduardo Caleiras, Ramón Álvarez-Esteban, José Antonio Pérez-Simón, Jose-Ignacio Rodriguez-Barbosa
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-03-01
Series:Frontiers in Immunology
Subjects:
HVEM: herpesvirus entry mediator
BTLA: B- and T-lymphocyte attenuator
PD-1: programmed death 1
Tim 3: T-cell immunoglobulin and mucin-domain containing-3
hybrid resistance
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1113858/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2023.1113858/full

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