Synthesis of both enantiomers and the 13C derivative of CPI-2850, the major metabolite of Devimistat

Synthesis of both enantiomers and the 13C derivative of CPI-2850, the major metabolite of Devimistat

A practical synthesis of CPI-2850, the major metabolite of Devimistat (CPI-613® (6,8-bis-benzylsulfanyloctanoic acid)), has been developed to synthesize multigram quantities for enantiomeric separation. Using enantioenriched (S)-(−)-1,2,4-butanetriol pure (S)-CPI-2850 enantiomer was synthesized to i...

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Bibliographic Details
Main Authors: Poli Adi Narayana Reddy, Zachary Stine, Joseph M. Salvino
Format: Article
Language:English
Published: Elsevier 2022-01-01
Series:Results in Chemistry
Subjects:
Devimistat
CPI-613®
CPI-2850
Single enantiomers
Enantioselective synthesis
Online Access:http://www.sciencedirect.com/science/article/pii/S2211715621001739

Internet

http://www.sciencedirect.com/science/article/pii/S2211715621001739

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