p21 induces a senescence program and skeletal muscle dysfunction

p21 induces a senescence program and skeletal muscle dysfunction

Recent work has established associations between elevated p21, the accumulation of senescent cells, and skeletal muscle dysfunction in mice and humans. Using a mouse model of p21 overexpression (p21OE), we examined if p21 mechanistically contributes to cellular senescence and pathological features i...

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Bibliographic Details
Main Authors: Davis A. Englund, Alyssa Jolliffe, Zaira Aversa, Xu Zhang, Ines Sturmlechner, Ayumi E. Sakamoto, Julianna D. Zeidler, Gina M. Warner, Colton McNinch, Thomas A. White, Eduardo N. Chini, Darren J. Baker, Jan M. van Deursen, Nathan K. LeBrasseur
Format: Article
Language:English
Published: Elsevier 2023-01-01
Series:Molecular Metabolism
Subjects:
Cellular senescence
DNA damage
Senescence-associated secretory phenotype
Aging
Sarcopenia
Physical function
Online Access:http://www.sciencedirect.com/science/article/pii/S2212877822002216

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http://www.sciencedirect.com/science/article/pii/S2212877822002216

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