Combination of metformin and phenformin synergistically inhibits proliferation and hTERT expression in human breast cancer cells

Combination of metformin and phenformin synergistically inhibits proliferation and hTERT expression in human breast cancer cells

Objective(s): Breast cancer remains a global challenge, and further chemopreventive therapies are still immediately required. Emerging evidence has revealed the potent anti-cancer effects of biguanides, Metformin (MET) and phenformin (PHE). Thus, to explore an efficient chemopreventive strategy for...

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Bibliographic Details
Main Authors: Davoud Jafari-Gharabaghlou, Younes Pilehvar-Soltanahmadi, Mehdi Dadashpour, Ali Mota, Soheila Vafajouy-Jamshidi, Leila Faramarzi, Sara Rasouli, Nosratollah Zarghami
Format: Article
Language:English
Published: Mashhad University of Medical Sciences 2018-11-01
Series:Iranian Journal of Basic Medical Sciences
Subjects:
Breast Cancer
Combination therapy
Metformin
Phenformin
Synergistic effects
Online Access:http://ijbms.mums.ac.ir/article_11432_cc0db53afe68f239a8a8cca027b1de07.pdf

Internet

http://ijbms.mums.ac.ir/article_11432_cc0db53afe68f239a8a8cca027b1de07.pdf

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