Effective methods for bulk RNA-seq deconvolution using scnRNA-seq transcriptomes

Effective methods for bulk RNA-seq deconvolution using scnRNA-seq transcriptomes

Abstract Background RNA profiling technologies at single-cell resolutions, including single-cell and single-nuclei RNA sequencing (scRNA-seq and snRNA-seq, scnRNA-seq for short), can help characterize the composition of tissues and reveal cells that influence key functions in both healthy and diseas...

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Main Authors: Francisco Avila Cobos, Mohammad Javad Najaf Panah, Jessica Epps, Xiaochen Long, Tsz-Kwong Man, Hua-Sheng Chiu, Elad Chomsky, Evgeny Kiner, Michael J. Krueger, Diego di Bernardo, Luis Voloch, Jan Molenaar, Sander R. van Hooff, Frank Westermann, Selina Jansky, Michele L. Redell, Pieter Mestdagh, Pavel Sumazin
Format: Article
Language:English
Published: BMC 2023-08-01
Series:Genome Biology
Online Access:https://doi.org/10.1186/s13059-023-03016-6

Internet

https://doi.org/10.1186/s13059-023-03016-6

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