Deletion of the Plasmodium falciparum exported protein PTP7 leads to Maurer's clefts vesiculation, host cell remodeling defects, and loss of surface presentation of EMP1.

Deletion of the Plasmodium falciparum exported protein PTP7 leads to Maurer's clefts vesiculation, host cell remodeling defects, and loss of surface presentation of EMP1.

Presentation of the variant antigen, Plasmodium falciparum erythrocyte membrane protein 1 (EMP1), at knob-like protrusions on the surface of infected red blood cells, underpins the parasite's pathogenicity. Here we describe a protein PF3D7_0301700 (PTP7), that functions at the nexus between the...

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Bibliographic Details
Main Authors: Olivia M S Carmo, Gerald J Shami, Dezerae Cox, Boyin Liu, Adam J Blanch, Snigdha Tiash, Leann Tilley, Matthew W A Dixon
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2022-08-01
Series:PLoS Pathogens
Online Access:https://doi.org/10.1371/journal.ppat.1009882

Internet

https://doi.org/10.1371/journal.ppat.1009882

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