The epitranscriptomic writer ALKBH8 drives tolerance and protects mouse lungs from the environmental pollutant naphthalene

The epitranscriptomic writer ALKBH8 drives tolerance and protects mouse lungs from the environmental pollutant naphthalene

The epitranscriptomic writer Alkylation Repair Homolog 8 (ALKBH8) is a transfer RNA (tRNA) methyltransferase that modifies the wobble uridine of selenocysteine tRNA to promote the specialized translation of selenoproteins. Using Alkbh8 deficient (Alkbh8def) mice, we have investigated the importance...

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Bibliographic Details
Main Authors: Andrea Leonardi, Nataliia Kovalchuk, Lei Yin, Lauren Endres, Sara Evke, Steven Nevins, Samuel Martin, Peter C. Dedon, J. Andres Melendez, Laura Van Winkle, Qing-Yu Zhang, Xinxin Ding, Thomas J. Begley
Format: Article
Language:English
Published: Taylor & Francis Group 2020-10-01
Series:Epigenetics
Subjects:
epitranscriptomics
rna modification
tolerance
naphthalene
alkbh8
selenoprotein
translation
stress response
Online Access:http://dx.doi.org/10.1080/15592294.2020.1750213

Internet

http://dx.doi.org/10.1080/15592294.2020.1750213

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