Interactions of 2-O-arachidonylglycerol ether and ibuprofen with the allosteric and catalytic subunits of human COX-21[S]

Interactions of 2-O-arachidonylglycerol ether and ibuprofen with the allosteric and catalytic subunits of human COX-21[S]

Prostaglandin (PG) endoperoxide H synthase (PGHS)-2, also known as cyclooxygenase (COX)-2, can convert arachidonic acid (AA) to PGH2 in the committed step of PG synthesis. PGHS-2 functions as a conformational heterodimer composed of an allosteric (Eallo) and a catalytic (Ecat) monomer. Here we inves...

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Bibliographic Details
Main Authors: Liang Dong, Hechang Zou, Chong Yuan, Yu H. Hong, Charis L. Uhlson, Robert C. Murphy, William L. Smith
Format: Article
Language:English
Published: Elsevier 2016-06-01
Series:Journal of Lipid Research
Subjects:
cyclooxygenase-2
prostaglandin, half-sites
2-arachindonoylglycerol
arachidonic acid
palmitic acid
ibuprofen
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520351816

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http://www.sciencedirect.com/science/article/pii/S0022227520351816

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