Pramlintide: A Novel Therapeutic Approach for Osteosarcoma through Metabolic Reprogramming

Despite aggressive combination chemotherapy and surgery, outcomes for patients with osteosarcoma have remained stagnant for more than 25 years, and numerous clinical trials have identified no new therapies. p53 deletion or mutation is found in more than 80% of osteosarcoma tumors. In p53-deficient c...

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Bibliographic Details
Main Authors: Yuanzheng Yang, Zhanglong Peng, Elsa R. Flores, Eugenie S. Kleinerman
Format: Article
Language:English
Published: MDPI AG 2022-09-01
Series:Cancers
Subjects:
Online Access:https://www.mdpi.com/2072-6694/14/17/4310