Metabolic reprogramming of oncogene-addicted cancer cells to OXPHOS as a mechanism of drug resistance

Metabolic reprogramming of oncogene-addicted cancer cells to OXPHOS as a mechanism of drug resistance

The ability to selectively eradicate oncogene-addicted tumors while reducing systemic toxicity has endeared targeted therapies as a treatment strategy. Nevertheless, development of acquired resistance limits the benefits and durability of such a regime. Here we report evidence of enhanced reliance o...

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Bibliographic Details
Main Authors: Jayshree Hirpara, Jie Qing Eu, Joanna Kia Min Tan, Andrea L. Wong, Marie-Veronique Clement, Li Ren Kong, Naoto Ohi, Takeshi Tsunoda, Jianhua Qu, Boon Cher Goh, Shazib Pervaiz
Format: Article
Language:English
Published: Elsevier 2019-07-01
Series:Redox Biology
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231718310747

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http://www.sciencedirect.com/science/article/pii/S2213231718310747

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