Membranolytic Mechanism of Amphiphilic Antimicrobial β-Stranded [KL]<sub>n</sub> Peptides

Membranolytic Mechanism of Amphiphilic Antimicrobial β-Stranded [KL]<sub>n</sub> Peptides

Amphipathic peptides can act as antibiotics due to membrane permeabilization. KL peptides with the repetitive sequence [Lys-Leu]<sub>n</sub>-NH<sub>2</sub> form amphipathic β-strands in the presence of lipid bilayers. As they are known to kill bacteria in a peculiar length-de...

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Bibliographic Details
Main Authors: Fabian Schweigardt, Erik Strandberg, Parvesh Wadhwani, Johannes Reichert, Jochen Bürck, Haroldo L. P. Cravo, Luisa Burger, Anne S. Ulrich
Format: Article
Language:English
Published: MDPI AG 2022-08-01
Series:Biomedicines
Subjects:
cationic antimicrobial peptides
length dependent activity
antimicrobial activity
hemolysis
vesicle leakage
solid-state <sup>31</sup>P-, <sup>15</sup>N- and <sup>19</sup>F-NMR
Online Access:https://www.mdpi.com/2227-9059/10/9/2071

Internet

https://www.mdpi.com/2227-9059/10/9/2071

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