Widespread and tissue-specific expression of endogenous retroelements in human somatic tissues

Widespread and tissue-specific expression of endogenous retroelements in human somatic tissues

Abstract Background Endogenous retroelements (EREs) constitute about 42% of the human genome and have been implicated in common human diseases such as autoimmunity and cancer. The dominant paradigm holds that EREs are expressed in embryonic stem cells (ESCs) and germline cells but are repressed in d...

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Main Authors: Jean-David Larouche, Assya Trofimov, Leslie Hesnard, Gregory Ehx, Qingchuan Zhao, Krystel Vincent, Chantal Durette, Patrick Gendron, Jean-Philippe Laverdure, Éric Bonneil, Caroline Côté, Sébastien Lemieux, Pierre Thibault, Claude Perreault
Format: Article
Language:English
Published: BMC 2020-04-01
Series:Genome Medicine
Subjects:
Endogenous retroelements
Immunopeptidome
Major histocompatibility complex
Medullary thymic epithelial cells
Somatic tissues
Systems biology
Online Access:http://link.springer.com/article/10.1186/s13073-020-00740-7

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http://link.springer.com/article/10.1186/s13073-020-00740-7

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