Evaluation of multidrug efflux pump inhibitors by a new method using microfluidic channels.

Evaluation of multidrug efflux pump inhibitors by a new method using microfluidic channels.

Fluorescein-di-β-D-galactopyranoside (FDG), a fluorogenic compound, is hydrolyzed by β-galactosidase in the cytoplasm of Escherichia coli to produce a fluorescent dye, fluorescein. We found that both FDG and fluorescein were substrates of efflux pumps, and have developed a new method to evaluate eff...

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Bibliographic Details
Main Authors: Yoshimi Matsumoto, Kohei Hayama, Shouichi Sakakihara, Kunihiko Nishino, Hiroyuki Noji, Ryota Iino, Akihito Yamaguchi
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3075257?pdf=render

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http://europepmc.org/articles/PMC3075257?pdf=render

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