HIV-1 Evolutionary Dynamics under Nonsuppressive Antiretroviral Therapy

HIV-1 Evolutionary Dynamics under Nonsuppressive Antiretroviral Therapy

ABSTRACT Prolonged virologic failure on 2nd-line protease inhibitor (PI)-based antiretroviral therapy (ART) without emergence of major protease mutations is well recognized and provides an opportunity to study within-host evolution in long-term viremic individuals. Using next-generation sequencing a...

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Bibliographic Details
Main Authors: Steven A. Kemp, Oscar J. Charles, Anne Derache, Werner Smidt, Darren P. Martin, Collins Iwuji, John Adamson, Katya Govender, Tulio de Oliveira, Francois Dabis, Deenan Pillay, Richard A. Goldstein, Ravindra K. Gupta
Format: Article
Language:English
Published: American Society for Microbiology 2022-06-01
Series:mBio
Subjects:
antiretroviral resistance
clinical failure
drug resistance evolution
human immunodeficiency virus
Online Access:https://journals.asm.org/doi/10.1128/mbio.00269-22

Internet

https://journals.asm.org/doi/10.1128/mbio.00269-22

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